Cullin 3 Antikörper (AA 411-510)
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- Target Alle Cullin 3 (CUL3) Antikörper anzeigen
- Cullin 3 (CUL3)
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Bindungsspezifität
- AA 411-510
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Cullin 3 Antikörper ist unkonjugiert
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Applikation
- ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Spezifität
- This antibody may detect Cullin-4 A/B
- Kreuzreaktivität
- Human
- Homologie
- Mouse,Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human Cullin 3
- Isotyp
- IgG
- Top Product
- Discover our top product CUL3 Primärantikörper
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- Applikationshinweise
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ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Haltbarkeit
- 12 months
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Tetrachlorobenzoquinone activates nrf2 signaling by keap1 cross-linking and ubiquitin translocation but not keap1-cullin3 complex dissociation." in: Chemical research in toxicology, Vol. 28, Issue 4, pp. 765-74, (2015) (PubMed).
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Tetrachlorobenzoquinone activates nrf2 signaling by keap1 cross-linking and ubiquitin translocation but not keap1-cullin3 complex dissociation." in: Chemical research in toxicology, Vol. 28, Issue 4, pp. 765-74, (2015) (PubMed).
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- Target
- Cullin 3 (CUL3)
- Andere Bezeichnung
- Cullin 3 (CUL3 Produkte)
- Synonyme
- CUL-3 antikoerper, Cullin-3 antikoerper, CUL-3-A antikoerper, Cullin-3-A antikoerper, cul3 antikoerper, cul3a antikoerper, CUL-3-B antikoerper, Cullin-3-B antikoerper, cul3b antikoerper, wu:fc37e01 antikoerper, CUL3 antikoerper, ATCUL3 antikoerper, ATCUL3A antikoerper, CUL3A antikoerper, T24P13.25 antikoerper, cullin 3 antikoerper, cullin 3A antikoerper, PHA2E antikoerper, AI467304 antikoerper, AW146203 antikoerper, mKIAA0617 antikoerper, cullin 3 antikoerper, cullin 3 L homeolog antikoerper, cullin 3 S homeolog antikoerper, cullin-3 antikoerper, Cullin-3 (CUL-3) antikoerper, cullin 3a antikoerper, CULlin antikoerper, CUL3 antikoerper, cul3 antikoerper, cul3.L antikoerper, cul3.S antikoerper, PTRG_11586 antikoerper, Smp_117580 antikoerper, cul3a antikoerper, Cul3 antikoerper, cul-3 antikoerper
- Hintergrund
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Synonyms: CUL-3, PHA2E, Cullin-3, CUL3, KIAA0617
Background: Core component of multiple cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the BCR complex depends on the BTB domain-containing protein as the substrate recognition component. BCR(KLHL42) is involved in ubiquitination of KATNA1. BCR(SPOP) is involved in ubiquitination of BMI1/PCGF4, BRMS1, H2AFY and DAXX, GLI2 and GLI3. Can also form a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL, these complexes have lower ubiquitin ligase activity. BCR(KLHL9-KLHL13) controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. BCR(KLHL12) is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). BCR(KLHL3) acts as a regulator of ion transport in the distal nephron, by mediating ubiquitination of WNK4. The BCR(KLHL20) E3 ubiquitin ligase complex is involved in interferon response and anterograde Golgi to endosome transport: it mediates both ubiquitination leading to degradation and 'Lys-33'-linked ubiquitination (PubMed:20389280, PubMed:21840486, PubMed:21670212, PubMed:24768539).
- Gen-ID
- 8452
- UniProt
- Q13618
- Pathways
- M Phase
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