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Cullin 3 Antikörper (AA 411-510)

CUL3 Reaktivität: Human ELISA, IHC (p), IF (cc), IF (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN705296
  • Target Alle Cullin 3 (CUL3) Antikörper anzeigen
    Cullin 3 (CUL3)
    Bindungsspezifität
    • 14
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 411-510
    Reaktivität
    • 51
    • 24
    • 19
    • 6
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    Human
    Wirt
    • 48
    • 2
    • 1
    Kaninchen
    Klonalität
    • 47
    • 4
    Polyklonal
    Konjugat
    • 30
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Cullin 3 Antikörper ist unkonjugiert
    Applikation
    • 24
    • 16
    • 12
    • 12
    • 12
    • 7
    • 6
    • 4
    • 2
    • 1
    • 1
    ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Spezifität
    This antibody may detect Cullin-4 A/B
    Kreuzreaktivität
    Human
    Homologie
    Mouse,Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Cullin 3
    Isotyp
    IgG
    Top Product
    Discover our top product CUL3 Primärantikörper
  • Applikationshinweise
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Su, Zhang, Song, Shi, Fu, Xia, Bai, Hu, Xu, Song, Song: "Tetrachlorobenzoquinone activates nrf2 signaling by keap1 cross-linking and ubiquitin translocation but not keap1-cullin3 complex dissociation." in: Chemical research in toxicology, Vol. 28, Issue 4, pp. 765-74, (2015) (PubMed).

  • Target
    Cullin 3 (CUL3)
    Andere Bezeichnung
    Cullin 3 (CUL3 Produkte)
    Synonyme
    CUL-3 antikoerper, Cullin-3 antikoerper, CUL-3-A antikoerper, Cullin-3-A antikoerper, cul3 antikoerper, cul3a antikoerper, CUL-3-B antikoerper, Cullin-3-B antikoerper, cul3b antikoerper, wu:fc37e01 antikoerper, CUL3 antikoerper, ATCUL3 antikoerper, ATCUL3A antikoerper, CUL3A antikoerper, T24P13.25 antikoerper, cullin 3 antikoerper, cullin 3A antikoerper, PHA2E antikoerper, AI467304 antikoerper, AW146203 antikoerper, mKIAA0617 antikoerper, cullin 3 antikoerper, cullin 3 L homeolog antikoerper, cullin 3 S homeolog antikoerper, cullin-3 antikoerper, Cullin-3 (CUL-3) antikoerper, cullin 3a antikoerper, CULlin antikoerper, CUL3 antikoerper, cul3 antikoerper, cul3.L antikoerper, cul3.S antikoerper, PTRG_11586 antikoerper, Smp_117580 antikoerper, cul3a antikoerper, Cul3 antikoerper, cul-3 antikoerper
    Hintergrund

    Synonyms: CUL-3, PHA2E, Cullin-3, CUL3, KIAA0617

    Background: Core component of multiple cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the BCR complex depends on the BTB domain-containing protein as the substrate recognition component. BCR(KLHL42) is involved in ubiquitination of KATNA1. BCR(SPOP) is involved in ubiquitination of BMI1/PCGF4, BRMS1, H2AFY and DAXX, GLI2 and GLI3. Can also form a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL, these complexes have lower ubiquitin ligase activity. BCR(KLHL9-KLHL13) controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. BCR(KLHL12) is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). BCR(KLHL3) acts as a regulator of ion transport in the distal nephron, by mediating ubiquitination of WNK4. The BCR(KLHL20) E3 ubiquitin ligase complex is involved in interferon response and anterograde Golgi to endosome transport: it mediates both ubiquitination leading to degradation and 'Lys-33'-linked ubiquitination (PubMed:20389280, PubMed:21840486, PubMed:21670212, PubMed:24768539).

    Gen-ID
    8452
    UniProt
    Q13618
    Pathways
    M Phase
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