BRCA2 Antikörper
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- Target Alle BRCA2 Antikörper anzeigen
- BRCA2 (Breast Cancer 2, Early Onset (BRCA2))
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser BRCA2 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Homologie
- Human
- Immunogen
- Recombinant human BRCA2_HUMAN.
- Klon
- F2H5
- Top Product
- Discover our top product BRCA2 Primärantikörper
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- Applikationshinweise
- WB 1:300-5000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 0.5 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- BRCA2 (Breast Cancer 2, Early Onset (BRCA2))
- Andere Bezeichnung
- BRCA2 (BRCA2 Produkte)
- Hintergrund
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Synonyms: BRCA 2, BRCA1/BRCA2 containing complex subunit 2, BRCC 2, BRCC2, Breast and ovarian cancer susceptibility gene early onset, Breast cancer 2 early onset, Breast Cancer 2 tumor suppressor, Breast cancer susceptibility protein BRCA2, Breast cancer type 2 susceptibility protein, FACD, FAD 1, FAD, FAD1, FANCB, FANCD 1, FANCD, FANCD1, Fanconi anemia complementation group D1, Fanconi anemia group D1 protein, OTTHUMP00000018803, OTTHUMP00000042401, BRCA2_HUMAN.
Background: Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. In concert with NPM1, regulates centrosome duplication.
- Gen-ID
- 675
- UniProt
- P51587
- Pathways
- DNA Reparatur, M Phase, Maintenance of Protein Location
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