DDX39B Antikörper (AA 1-100)

Produktnummer ABIN7091025

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch DDX39B in ELISA und WB. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für DDX39B Antikörper (AA 1-100) (ABIN7091025)

Target: DDX39B (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 39B (DDX39B))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DDX39B Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Produktdetails anti-DDX39B Antikörper

Bindungsspezifität: AA 1-100

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Cow,Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human UAP56

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu DDX39B

Target: DDX39B (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 39B (DDX39B))

Andere Bezeichnung: UAP56

Hintergrund:

Synonyms: 56 kDa U2AF65-associated protein, ATP-dependent RNA helicase p47, B(0,+)-type amino acid transporter 1, BAT1, Bat1a, DEAD box protein UAP56, Glycoprotein-associated amino acid transporter b0,+AT1, HLA-B-associated transcript 1 protein, HLA-B-associated transcript 1A, HLA-B-associated transcript-1, p47, Solute carrier family 7 member 9, Spliceosome RNA helicase BAT1, UAP56, 56 kDa U2AF65-associated protein, ATP-dependent RNA helicase p47, 0610030D10Rik, 4F2-LC6, AI428441, D17H6S81E, D17H6S81E-1, D6S81E, D6S81Eh, DDX39B, DX39B_HUMAN, Glycoprotein-associated amino acid transporter b0,+AT1, MGC127051, MGC19235, MGC38799, nuclear RNA helicase (DEAD family), OTTHUMP00000029229, OTTHUMP00000165889, OTTHUMP00000165890, Spliceosome RNA helicase DDX39B, U2AF65-associayed protein, 56-KD.

Background: Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC4 and the THO complex. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and ALYREF/THOC4. Splice factor that is required for the first ATP-dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint. Has both RNA-stimulated ATP binding/hydrolysis activity and ATP-dependent RNA unwinding activity. Even with the stimulation of RNA, the ATPase activity is weak. Can only hydrolyze ATP but not other NTPs. The RNA stimulation of ATPase activity does not have a strong preference for the sequence and length of the RNA. However, ssRNA stimulates the ATPase activity much more strongly than dsRNA. Can unwind 5' or 3' overhangs or blunt end RNA duplexes in vitro. The ATPase and helicase activities are not influenced by U2AF2 and ALYREF/THOC4.

Gen-ID: 7919

UniProt: Q13838

Pathways: Ribonucleoprotein Complex Subunit Organization