RNF4 Antikörper

Produktnummer ABIN7091651

Produktdetails anti-RNF4 Antikörper

Target: RNF4 (Ring Finger Protein 4 (RNF4))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser RNF4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Homologie: Human

Immunogen: Recombinant human RNF4.

Klon: E4R2

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu RNF4

Target: RNF4 (Ring Finger Protein 4 (RNF4))

Andere Bezeichnung: RNF4 (RNF4 Produkte)

Synonyme: SLX5 antikoerper, SNURF antikoerper, AU018689 antikoerper, Gtrgeo8 antikoerper, ring finger protein 4 antikoerper, RNF4 antikoerper, Rnf4 antikoerper

Hintergrund:

Synonyms: RNF4_HUMAN, E3 ubiquitin ligase RNF4, E3 ubiquitin protein ligase RNF4, Protein SNURF, RES4 26, RING finger protein 4, SLX5, Small nuclear ring finger protein, SNURF.

Background: E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation.

Gen-ID: 6047

UniProt: P78317

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway