RBX1 Antikörper (AA 1-108)

Produktnummer ABIN7091652

Produktdetails anti-RBX1 Antikörper

Target: RBX1 (Ring-Box 1, E3 Ubiquitin Protein Ligase (RBX1))

Bindungsspezifität: AA 1-108

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser RBX1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Homologie: Human,Mouse

Immunogen: Recombinant human RBX1 between 1-108 amino acids.

Klon: C8F22

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu RBX1

Target: RBX1 (Ring-Box 1, E3 Ubiquitin Protein Ligase (RBX1))

Andere Bezeichnung: RBX1 (RBX1 Produkte)

Hintergrund:

Synonyms: E3 ubiquitin-protein ligase RBX1, MGC13357, MGC1481, Protein ZYP, Rbx 1, Rbx1, RBX1_HUMAN, Regulator of Cullins 1, Ring box 1, RING box protein 1, RING finger protein 75, RING finger protein, RING-box protein 1, Ringbox protein 1, RNF 75, RNF75, ROC 1, ROC1, ZYP protein.

Background: E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41.

Gen-ID: 9978

UniProt: P62877

Pathways: Zellzyklus, M Phase, SARS-CoV-2 Protein Interaktom