SREBF chaperone Antikörper (AA 41-140)

Produktnummer ABIN7091694

Produktdetails anti-SREBF chaperone Antikörper

Target: SREBF chaperone (SCAP)

Bindungsspezifität: AA 41-140

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SREBF chaperone Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Homologie: Human

Immunogen: KLH conjugated synthetic peptide derived from human SCAP

Klon: B7T5

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu SREBF chaperone

Target: SREBF chaperone (SCAP)

Andere Bezeichnung: SCAP (SCAP Produkte)

Synonyme: 9530044G19 antikoerper, mKIAA0199 antikoerper, SREBF chaperone antikoerper, SREBF chaperone S homeolog antikoerper, SCAP antikoerper, Scap antikoerper, scap.S antikoerper

Hintergrund:

Synonyms: KIAA0199, SCAP_HUMAN, SREBF chaperone, SREBF chaperone protein, SREBP cleavage activating protein, SREBP cleavage-activating protein, Sterol regulatory element binding protein cleavage-activating protein, Sterol regulatory element-binding protein cleavage-activating protein.

Background: Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway.

Gen-ID: 22937

UniProt: Q12770

Pathways: SARS-CoV-2 Protein Interaktom