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AP2A2 Antikörper

Dieses Anti-AP2A2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von AP2A2 in WB, IHC und ELISA. Geeignet für Human, Maus und Ratte.
Produktnummer ABIN7111308

Kurzübersicht für AP2A2 Antikörper (ABIN7111308)

Target

Alle AP2A2 Antikörper anzeigen
AP2A2 (Adaptor-Related Protein Complex 2, alpha 2 Subunit (AP2A2))

Reaktivität

  • 40
  • 28
  • 12
  • 3
  • 2
  • 1
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 39
  • 1
Kaninchen

Klonalität

  • 40
Polyklonal

Konjugat

  • 14
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser AP2A2 Antikörper ist unkonjugiert

Applikation

  • 33
  • 13
  • 13
  • 13
  • 5
  • 4
  • 3
  • 3
  • 3
  • 2
  • 2
Western Blotting (WB), Immunohistochemistry (IHC), ELISA
  • Aufreinigung

    Immunogen affinity purified

    Reinheit

    ≥95 % as determined by SDS-PAGE

    Immunogen

    adaptor-related protein complex 2, alpha 2 subunit

    Isotyp

    IgG
  • Applikationshinweise

    WB: 1:200-1:1000, IHC: 1:20-1:200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

    Haltbarkeit

    12 months
  • Target

    AP2A2 (Adaptor-Related Protein Complex 2, alpha 2 Subunit (AP2A2))

    Andere Bezeichnung

    AP2A2

    Hintergrund

    Synonyms:ADTAB, CLAPA2, HIP9, HYPJ, KIAA0899 Background:Component of the adaptor protein complex 2(AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin(clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein(AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV](Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif(By similarity).

    Molekulargewicht

    104 kDa

    Gen-ID

    161

    UniProt

    O94973

    Pathways

    EGFR Signaling Pathway, Neurotrophin Signalübertragung, EGFR Downregulation, SARS-CoV-2 Protein Interaktom
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