AFAR antikoerper, AFAR1 antikoerper, AFB1-AR1 antikoerper, AKR7 antikoerper, Aiar antikoerper, akr7a2 antikoerper, aldo-keto reductase family 7 member A2 antikoerper, aldo-keto reductase family 7, member A2 antikoerper, aldo-keto reductase family 7, member A2 L homeolog antikoerper, AKR7A2 antikoerper, Akr7a2 antikoerper, akr7a2.L antikoerper
Hintergrund
Synonyms:AFAR, AFAR1, AFB1 aldehyde reductase 1, AFB1 AR 1, AFB1 AR1, AKR7, AKR7A2, Aldoketoreductase 7, SSA reductase Background:The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. Alternative splicing results in multiple transcript variants.