ANKRD15 Antikörper

Produktnummer ABIN7111596

Produktdetails anti-ANKRD15 Antikörper

Target: ANKRD15 (Ankyrin Repeat Domain 15 (ANKRD15))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ANKRD15 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC)

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: KN motif and ankyrin repeat domains 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu ANKRD15

Target: ANKRD15 (Ankyrin Repeat Domain 15 (ANKRD15))

Andere Bezeichnung: KANK1 (ANKRD15 Produkte)

Synonyme: ANKRD15 antikoerper, CPSQ2 antikoerper, KANK antikoerper, A930031B09Rik antikoerper, AU015049 antikoerper, AW121052 antikoerper, Ankrd15 antikoerper, D330024H06Rik antikoerper, mKIAA0172 antikoerper, KANK1 antikoerper, ankrd15 antikoerper, kank1.2 antikoerper, DMRT1 antikoerper, KN motif and ankyrin repeat domains 1 antikoerper, KN motif and ankyrin repeat domains 1 L homeolog antikoerper, doublesex and mab-3 related transcription factor 1 antikoerper, KANK1 antikoerper, Kank1 antikoerper, kank1.L antikoerper, DMRT1 antikoerper

Hintergrund: Synonyms:ANKRD15, KANK, KIAA0172 Background:Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration. Inhibits RhoA activity, the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia, the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading, the function is partially mediated by BAIAP2. Inhibits neurite outgrowth. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. In the nucleus, is involved in beta-catenin-dependent activation of transcription. Potential tumor suppressor for renal cell carcinoma.

Molekulargewicht: 75-85kd,30kd

Gen-ID: 23189

UniProt: Q14678

Pathways: Regulation of Actin Filament Polymerization