chmp6 antikoerper, vps20 antikoerper, 2400004G01Rik antikoerper, VPS20 antikoerper, RGD1565325 antikoerper, chmp6l antikoerper, flj11749l antikoerper, wu:fb79d02 antikoerper, zgc:110067 antikoerper, charged multivesicular body protein 6 antikoerper, charged multivesicular body protein 6 L homeolog antikoerper, charged multivesicular body protein 6 S homeolog antikoerper, charged multivesicular body protein 6b antikoerper, LOC100280982 antikoerper, chmp6.L antikoerper, chmp6.S antikoerper, CHMP6 antikoerper, chmp6 antikoerper, Tsp_08316 antikoerper, Chmp6 antikoerper, chmp6b antikoerper
Hintergrund
Synonyms:VPS20 Background:Probable core component of the endosomal sorting required for transport complex III(ESCRT-III) which is involved in multivesicular bodies(MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles(ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O,-I,-II and-III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses(HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes.