DNA Helicase B Antikörper
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- Target Alle DNA Helicase B (HELB) Antikörper anzeigen
- DNA Helicase B (HELB)
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser DNA Helicase B Antikörper ist unkonjugiert
- Applikation
- Western Blotting (WB), ELISA, Immunofluorescence (IF)
- Aufreinigung
- Immunogen affinity purified
- Reinheit
- ≥95 % as determined by SDS-PAGE
- Immunogen
- helicase(DNA) B
- Isotyp
- IgG
- Top Product
- Discover our top product HELB Primärantikörper
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anti-DNA Helicase B (HELB) (AA 77-126) antibody
HELB Reaktivität: Human, Schwein, Affe WB Wirt: Kaninchen Polyclonal unconjugated
anti-DNA Helicase B (HELB) (N-Term) antibodyHELB Reaktivität: Human, Schwein, Rind (Kuh), Meerschweinchen, Ratte WB Wirt: Kaninchen Polyclonal unconjugated
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- Applikationshinweise
- WB: 1:500-1:2000, IF: 1:20-1:200
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
- Haltbarkeit
- 12 months
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- Target
- DNA Helicase B (HELB)
- Andere Bezeichnung
- HELB (HELB Produkte)
- Synonyme
- RGD1560103 antikoerper, hDHB antikoerper, AI447783 antikoerper, D10Ertd664e antikoerper, DNA helicase B antikoerper, helicase (DNA) B antikoerper, Helb antikoerper, HELB antikoerper
- Hintergrund
- Synonyms: Background:5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection(PubMed:25617833, PubMed:26774285). Recruitment to single-stranded DNA(ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5'-3' ssDNA translocase activity of HELB(PubMed:26774285). As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation(PubMed:26774285). Acts independently of TP53BP1(PubMed:26774285). Unwinds duplex DNA with 5'-3' polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates(PubMed:12181327). During S phase, may facilitate cellular recovery from replication stress(PubMed:22194613).
- Molekulargewicht
- 120-140 kDa
- Gen-ID
- 391723
- UniProt
- Q8NG08
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