NEIL1 Antikörper

Produktnummer ABIN7113799

Produktdetails anti-NEIL1 Antikörper

Target: NEIL1 (Endonuclease VIII-Like 1 (NEIL1))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NEIL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: nei endonuclease VIII-like 1(E. coli)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu NEIL1

Target: NEIL1 (Endonuclease VIII-Like 1 (NEIL1))

Andere Bezeichnung: NEIL1 (NEIL1 Produkte)

Synonyme: FPG1 antikoerper, NEI1 antikoerper, hFPG1 antikoerper, 2810450N13Rik antikoerper, Nei1 antikoerper, nei-like DNA glycosylase 1 antikoerper, nei like DNA glycosylase 1 antikoerper, nei endonuclease VIII-like 1 (E. coli) antikoerper, Neil1 antikoerper, NEIL1 antikoerper

Hintergrund: Synonyms:DNA glycosylase/AP lyase Neil1, Endonuclease 8 like 1, Endonuclease VIII like 1, FPG1, hFPG1, NEH1, Nei homolog 1, Nei like protein 1, NEI1, NEIL1 Background:Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine(Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP(apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'-and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine(5hmC), suggesting that it acts as a specific reader of 5hmC.

Molekulargewicht: 44kd

Gen-ID: 79661

UniProt: Q96FI4

Pathways: DNA Reparatur