EYA2 Antikörper

Produktnummer ABIN7114029

Produktdetails anti-EYA2 Antikörper

Target: EYA2 (Eyes Absent Homolog 2 (Drosophila) (EYA2))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EYA2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: eyes absent homolog 2(Drosophila)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IHC: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu EYA2

Target: EYA2 (Eyes Absent Homolog 2 (Drosophila) (EYA2))

Andere Bezeichnung: EYA2 (EYA2 Produkte)

Synonyme: EYA2 antikoerper, zgc:92279 antikoerper, eab1 antikoerper, Eab1 antikoerper, EAB1 antikoerper, EYA transcriptional coactivator and phosphatase 2 antikoerper, EYA2 antikoerper, eya2 antikoerper, Eya2 antikoerper

Hintergrund: Synonyms:EAB1 Background:Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5(PubMed:12500905, PubMed:23435380). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX(H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress(PubMed:19351884). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2, in this it is functionally redundant with EYA1(PubMed:12500905).

Molekulargewicht: 57 kDa

Gen-ID: 2139

UniProt: O00167