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KPNA5 Antikörper

KPNA5 Reaktivität: Human, Maus, Ratte WB, ELISA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7115574
  • Target Alle KPNA5 Antikörper anzeigen
    KPNA5 (Karyopherin alpha 5 (Importin alpha 6) (KPNA5))
    Reaktivität
    • 26
    • 6
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 25
    • 1
    Kaninchen
    Klonalität
    • 25
    • 1
    Polyklonal
    Konjugat
    • 16
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser KPNA5 Antikörper ist unkonjugiert
    Applikation
    • 25
    • 18
    • 6
    • 4
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), ELISA
    Aufreinigung
    Immunogen affinity purified
    Reinheit
    ≥95 % as determined by SDS-PAGE
    Immunogen
    karyopherin alpha 5(importin alpha 6)
    Isotyp
    IgG
    Top Product
    Discover our top product KPNA5 Primärantikörper
  • Applikationshinweise
    WB: 1:500-1:2000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    Haltbarkeit
    12 months
  • Target
    KPNA5 (Karyopherin alpha 5 (Importin alpha 6) (KPNA5))
    Andere Bezeichnung
    KPNA5 (KPNA5 Produkte)
    Synonyme
    IPOA6 antikoerper, SRP6 antikoerper, Ipoa6 antikoerper, im:7151662 antikoerper, zgc:110662 antikoerper, karyopherin subunit alpha 5 antikoerper, karyopherin alpha 5 (importin alpha 6) antikoerper, KPNA5 antikoerper, Kpna5 antikoerper, kpna5 antikoerper
    Hintergrund
    Synonyms: Background:Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex(NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and-beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.
    Molekulargewicht
    60 kDa
    Gen-ID
    3841
    UniProt
    O15131
    Pathways
    Protein targeting to Nucleus
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