KLHL20 Antikörper

Produktnummer ABIN7115597

Produktdetails anti-KLHL20 Antikörper

Target: KLHL20 (Kelch-Like 20 (KLHL20))

Reaktivität: Ratte, Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KLHL20 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: kelch-like 20(Drosophila)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IHC: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu KLHL20

Target: KLHL20 (Kelch-Like 20 (KLHL20))

Andere Bezeichnung: KLHL20 (KLHL20 Produkte)

Synonyme: fc33f09 antikoerper, zgc:66288 antikoerper, wu:fc33f09 antikoerper, khlhx antikoerper, kleip antikoerper, klhlx antikoerper, AI504637 antikoerper, D930050H05Rik antikoerper, Kleip antikoerper, mKIAA4210 antikoerper, KHLHX antikoerper, KLEIP antikoerper, KLHLX antikoerper, RP3-383J4.3 antikoerper, RGD1309490 antikoerper, kelch-like family member 20 antikoerper, kelch like family member 20 L homeolog antikoerper, kelch like family member 20 antikoerper, kelch-like 20 antikoerper, klhl20 antikoerper, klhl20.L antikoerper, KLHL20 antikoerper, Klhl20 antikoerper

Hintergrund: Synonyms:KLEIP Background:Substrate-specific adapter of a BCR(BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis(PubMed:20389280). The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates 'Lys-33'-linked ubiquitination(PubMed:24768539). Involved in anterograde Golgi to endosome transport by mediating 'Lys-33'-linked ubiquitination of CORO7, promoting interaction between CORO7 and EPS15, thereby facilitating actin polymerization and post-Golgi trafficking(PubMed:24768539). Also acts as a regulator of endothelial migration during angiogenesis by controlling the activation of Rho GTPases. The BCR(KLHL20) E3 ubiquitin ligase complex acts as a regulator of neurite outgrowth by mediating ubiquitination and degradation of PDZ-RhoGEF/ARHGEF11(PubMed:21670212). In case of tumor, the BCR(KLHL20) E3 ubiquitin ligase complex is involved in tumor hypoxia: following hypoxia, the BCR(KLHL20)complex mediates ubiquitination and degradation of PML, potentiating HIF-1 signaling and cancer progression(PubMed:21840486).

Molekulargewicht: 65-67kd

Gen-ID: 27252

UniProt: Q9Y2M5