KIF7 Antikörper

Produktnummer ABIN7115710

Produktdetails anti-KIF7 Antikörper

Target: KIF7 (Kinesin Family Member 7 (KIF7))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KIF7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: kinesin family member 7

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IP: 1:500-1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu KIF7

Target: KIF7 (Kinesin Family Member 7 (KIF7))

Andere Bezeichnung: KIF7 (KIF7 Produkte)

Synonyme: KIF7 antikoerper, DDBDRAFT_0204609 antikoerper, DDBDRAFT_0206583 antikoerper, DDB_0204609 antikoerper, DDB_0206583 antikoerper, ACLS antikoerper, HLS2 antikoerper, JBTS12 antikoerper, UNQ340 antikoerper, cos2 antikoerper, costal2 antikoerper, kinesin family member 7 antikoerper, KIF7 antikoerper, kif7 antikoerper, Kif7 antikoerper

Hintergrund: Synonyms:KIF7, kinesin family member 7, Kinesin like protein KIF7, UNQ340 Background:Essential for hedgehog signaling regulation: acts as both a negative and positive regulator of sonic hedgehog(Shh) and Indian hedgehog(Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and-independent mechanisms(PubMed:21633164). Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes(By similarity). Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation(By similarity). Involved in the regulation of epidermal differentiation and chondrocyte development(By similarity).

Molekulargewicht: 150 kDa

Gen-ID: 374654

UniProt: Q2M1P5

Pathways: Hedgehog Signalweg