MMS19 Antikörper

Produktnummer ABIN7116477

Produktdetails anti-MMS19 Antikörper

Target: MMS19 (MMS19 Nucleotide Excision Repair Homolog (MMS19))

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MMS19 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC)

Aufreinigung: Protein A+G purification

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: MMS19 nucleotide excision repair homolog(S. cerevisiae)

Klon: 6H1

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: WB: 1:1000-1:4000, IHC: 1:20-1:200, IF: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu MMS19

Target: MMS19 (MMS19 Nucleotide Excision Repair Homolog (MMS19))

Andere Bezeichnung: MMS19 (MMS19 Produkte)

Synonyme: MET18 antikoerper, MMS19L antikoerper, hMMS19 antikoerper, 2410001K24Rik antikoerper, 2610042O15Rik antikoerper, AI316855 antikoerper, C79368 antikoerper, C86341 antikoerper, Mms19l antikoerper, mms19 antikoerper, mms19l antikoerper, MMS19 homolog, cytosolic iron-sulfur assembly component antikoerper, MMS19 (MET18 S. cerevisiae) antikoerper, MMS19 homolog, cytosolic iron-sulfur assembly component L homeolog antikoerper, MMS19 antikoerper, Mms19 antikoerper, mms19.L antikoerper

Hintergrund: Synonyms:MMS19L Background:Key component of the cytosolic iron-sulfur protein assembly(CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair(NER) and RNA polymerase II(POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor(ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.

Molekulargewicht: 103 kDa

Gen-ID: 64210

UniProt: Q96T76

Pathways: Nuclear Hormone Receptor Binding