MCC Antikörper
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- Target Alle MCC Antikörper anzeigen
- MCC (Mutated in Colorectal Cancers (MCC))
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Reaktivität
- Human, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser MCC Antikörper ist unkonjugiert
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Applikation
- ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)
- Aufreinigung
- Immunogen affinity purified
- Reinheit
- ≥95 % as determined by SDS-PAGE
- Immunogen
- mutated in colorectal cancers
- Isotyp
- IgG
- Top Product
- Discover our top product MCC Primärantikörper
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anti-Mutated in Colorectal Cancers (MCC) (AA 1-829) antibody
MCC Reaktivität: Human WB, IP Wirt: Kaninchen Polyclonal unconjugated
anti-Mutated in Colorectal Cancers (MCC) (AA 31-130) antibodyMCC Reaktivität: Human ELISA, WB, RNAi Wirt: Maus Monoclonal 1A7 unconjugated
anti-Mutated in Colorectal Cancers (MCC) (AA 479-611) antibodyMCC Reaktivität: Human ELISA, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Mutated in Colorectal Cancers (MCC) (Center) antibodyMCC Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
anti-Mutated in Colorectal Cancers (MCC) (AA 473-501) antibodyMCC Reaktivität: Human WB Wirt: Kaninchen Polyclonal RB37047 unconjugated
anti-Mutated in Colorectal Cancers (MCC) (AA 31-130) antibodyMCC Reaktivität: Human ELISA, WB Wirt: Maus Polyclonal unconjugated
anti-Mutated in Colorectal Cancers (MCC) (AA 1-829) antibodyMCC Reaktivität: Human WB Wirt: Maus Polyclonal unconjugated
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- Applikationshinweise
- WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200, IF: 1:20-1:200
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
- Haltbarkeit
- 12 months
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- Target
- MCC (Mutated in Colorectal Cancers (MCC))
- Andere Bezeichnung
- MCC (MCC Produkte)
- Hintergrund
- Synonyms: Background:Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase(PAK) activation(PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway(canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin(CTNB1) transcriptional activity(PubMed:24824780).
- Molekulargewicht
- 98 kDa , 113-118 kDa
- Gen-ID
- 4163
- UniProt
- P23508
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