PAN2 Antikörper

Produktnummer ABIN7117214

Der Kaninchen Polyklonal Anti-PAN2-Antikörper wurde für ELISA, WB und IHC validiert. Er ist geeignet, PAN2 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für PAN2 Antikörper (ABIN7117214)

Target: PAN2 (PAN2 Poly(A) Specific Ribonuclease Subunit Homolog (PAN2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PAN2 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-PAN2 Antikörper

Verwendungszweck: PAN2 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: PAN2 poly(A) specific ribonuclease subunit homolog

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IHC: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu PAN2

Target: PAN2 (PAN2 Poly(A) Specific Ribonuclease Subunit Homolog (PAN2))

Andere Bezeichnung: PAN2

Hintergrund:

Synonyms: PAN2-PAN3 deadenylation complex catalytic subunit PAN2|Inactive ubiquitin carboxyl-terminal hydrolase 52|PAB1P-dependent poly(A)-specific ribonuclease|Poly(A)-nuclease deadenylation complex subunit 2 (PAN deadenylation complex subunit 2)|PAN2|KIAA0710|USP52

Background: Catalytic subunit of the poly(A)-nuclease(PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein(PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.

Molekulargewicht: 127 kDa

Gen-ID: 9924

UniProt: Q504Q3