PELI2 Antikörper

Produktnummer ABIN7117276

Produktdetails anti-PELI2 Antikörper

Target: PELI2 (Pellino Homolog 2 (Drosophila) (PELI2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PELI2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: pellino homolog 2(Drosophila)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu PELI2

Target: PELI2 (Pellino Homolog 2 (Drosophila) (PELI2))

Andere Bezeichnung: PELI2 (PELI2 Produkte)

Synonyme: AW047589 antikoerper, BB129927 antikoerper, pellino 2 antikoerper, pellino E3 ubiquitin protein ligase family member 2 antikoerper, Peli2 antikoerper, PELI2 antikoerper

Hintergrund: Synonyms: Background:E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS-and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP(mitogen activated protein) kinase pathway leading to activation of ELK1.

Molekulargewicht: 45-50 kDa

Gen-ID: 57161

UniProt: Q9HAT8

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades