wu:fa95b11 antikoerper, zgc:110435 antikoerper, HSRBP4 antikoerper, HSRPB4 antikoerper, RBP4 antikoerper, RPB16 antikoerper, 2310002G05Rik antikoerper, 2610028L19Rik antikoerper, RNA polymerase II subunit D antikoerper, DNA-directed RNA polymerase II 16 kDa polypeptide antikoerper, polymerase (RNA) II (DNA directed) polypeptide D antikoerper, Polr2d antikoerper, CpipJ_CPIJ006734 antikoerper, UREG_01395 antikoerper, LOC100282338 antikoerper, polr2d antikoerper, POLR2D antikoerper
Hintergrund
Synonyms: Background:DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA(By similarity).