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REST Antikörper

REST Reaktivität: Human, Ratte WB, ELISA, IP Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7118333
  • Target Alle REST Antikörper anzeigen
    REST (RE1-Silencing Transcription Factor (REST))
    Reaktivität
    • 41
    • 9
    • 8
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Human, Ratte
    Wirt
    • 40
    • 1
    Kaninchen
    Klonalität
    • 40
    • 1
    Polyklonal
    Konjugat
    • 23
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser REST Antikörper ist unkonjugiert
    Applikation
    • 27
    • 17
    • 9
    • 7
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunoprecipitation (IP)
    Aufreinigung
    Immunogen affinity purified
    Reinheit
    ≥95 % as determined by SDS-PAGE
    Immunogen
    RE1-silencing transcription factor
    Isotyp
    IgG
    Top Product
    Discover our top product REST Primärantikörper
  • Applikationshinweise
    WB: 1:500-1:1000, IP: 1:500-1:2000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    Haltbarkeit
    12 months
  • Target
    REST (RE1-Silencing Transcription Factor (REST))
    Andere Bezeichnung
    REST (REST Produkte)
    Hintergrund
    Synonyms:NRSF, REST, X2 box repressor, XBR Background:Transcriptional repressor which binds neuron-restrictive silencer element(NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression.
    Molekulargewicht
    122 kDa, 200kd
    Gen-ID
    5978
    UniProt
    Q13127
    Pathways
    Negative Regulation of Hormone Secretion, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Chromatin Binding, Positive Regulation of Endopeptidase Activity
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