RGS14 Antikörper

Produktnummer ABIN7118377

Produktdetails anti-RGS14 Antikörper

Target: RGS14 (Regulator of G-Protein Signaling 14 (RGS14))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RGS14 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: regulator of G-protein signaling 14

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IP: 1:200-1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu RGS14

Target: RGS14 (Regulator of G-Protein Signaling 14 (RGS14))

Andere Bezeichnung: RGS14 (RGS14 Produkte)

Synonyme: RPIP1 antikoerper, MGC80558 antikoerper, RGS14 antikoerper, rgs14 antikoerper, wu:fi04g12 antikoerper, regulator of G protein signaling 14 antikoerper, regulator of G-protein signaling 14 antikoerper, regulator of G-protein signaling 14 L homeolog antikoerper, regulator of G-protein signalling 14 antikoerper, regulator of G protein signaling 14a antikoerper, RGS14 antikoerper, Rgs14 antikoerper, rgs14.L antikoerper, rgs14 antikoerper, rgs14a antikoerper

Hintergrund: Synonyms: Background:Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor(GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o) alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor(PDGF)-stimulated ERK1/ERK2 phosphorylation, a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor(NGF)-mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal-based learning and memory.

Molekulargewicht: 60-65 kDa

Gen-ID: 10636

UniProt: O43566

Pathways: Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Platelet-derived growth Factor Receptor Signaling