RFWD3 Antikörper

Produktnummer ABIN7118631

Produktdetails anti-RFWD3 Antikörper

Target: RFWD3 (Ring Finger and WD Repeat Domain 3 (RFWD3))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RFWD3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: ring finger and WD repeat domain 3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu RFWD3

Target: RFWD3 (Ring Finger and WD Repeat Domain 3 (RFWD3))

Andere Bezeichnung: RFWD3 (RFWD3 Produkte)

Synonyme: RGD1305243 antikoerper, RFWD3 antikoerper, RNF201 antikoerper, BC027246 antikoerper, ring finger and WD repeat domain 3 antikoerper, Rfwd3 antikoerper, RFWD3 antikoerper

Hintergrund: Synonyms:RNF201 Background:E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. Plays a role in RPA-mediated DNA damage signaling and repair.

Molekulargewicht: 85 kDa

Gen-ID: 55159

UniProt: Q6PCD5