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RNF41 Antikörper

RNF41 Reaktivität: Human, Maus, Ratte WB, ELISA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7118659
  • Target Alle RNF41 Antikörper anzeigen
    RNF41 (Ring Finger Protein 41 (RNF41))
    Reaktivität
    • 35
    • 15
    • 11
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 31
    • 4
    Kaninchen
    Klonalität
    • 34
    • 1
    Polyklonal
    Konjugat
    • 18
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser RNF41 Antikörper ist unkonjugiert
    Applikation
    • 28
    • 19
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA
    Aufreinigung
    Immunogen affinity purified
    Reinheit
    ≥95 % as determined by SDS-PAGE
    Immunogen
    ring finger protein 41
    Isotyp
    IgG
    Top Product
    Discover our top product RNF41 Primärantikörper
  • Applikationshinweise
    WB: 1:500-1:2000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    Haltbarkeit
    12 months
  • Target
    RNF41 (Ring Finger Protein 41 (RNF41))
    Andere Bezeichnung
    RNF41 (RNF41 Produkte)
    Synonyme
    FLRF antikoerper, NRDP1 antikoerper, 2210404G21Rik antikoerper, 4930511A05Rik antikoerper, 4933415P08Rik antikoerper, D10Ertd722e antikoerper, Nrdp1 antikoerper, wu:fi13f07 antikoerper, wu:fi25b06 antikoerper, zgc:55389 antikoerper, flrf antikoerper, ring finger protein 41 antikoerper, ring finger protein 41 S homeolog antikoerper, ring finger protein 41, E3 ubiquitin protein ligase antikoerper, RNF41 antikoerper, Rnf41 antikoerper, rnf41 antikoerper, rnf41.S antikoerper
    Hintergrund
    Synonyms:FLRF, NRDP1 Background:Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus(By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin(EPO) and interleukin-3(IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages(By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state. The RNF41-PARK2 pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control(PubMed:24949970).
    Molekulargewicht
    36 kDa
    Gen-ID
    10193
    UniProt
    Q9H4P4
    Pathways
    SARS-CoV-2 Protein Interaktom
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