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SH2D1B Antikörper

SH2D1B Reaktivität: Human, Maus, Ratte ELISA, IHC, WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7119007
  • Target Alle SH2D1B Antikörper anzeigen
    SH2D1B (SH2 Domain Containing 1B (SH2D1B))
    Reaktivität
    Human, Maus, Ratte
    Wirt
    • 17
    • 5
    • 2
    Kaninchen
    Klonalität
    • 21
    • 3
    Polyklonal
    Konjugat
    • 14
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SH2D1B Antikörper ist unkonjugiert
    Applikation
    • 11
    • 9
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
    Aufreinigung
    Immunogen affinity purified
    Reinheit
    ≥95 % as determined by SDS-PAGE
    Immunogen
    SH2 domain containing 1B
    Isotyp
    IgG
    Top Product
    Discover our top product SH2D1B Primärantikörper
  • Applikationshinweise
    WB: 1:500-1:2000, IHC: 1:20-1:200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    Haltbarkeit
    12 months
  • Target
    SH2D1B (SH2 Domain Containing 1B (SH2D1B))
    Andere Bezeichnung
    SH2D1B (SH2D1B Produkte)
    Synonyme
    EAT2 antikoerper, Sh2d1b1 antikoerper, RGD1563935 antikoerper, SH2 domain containing 1B antikoerper, SH2D1B antikoerper, Sh2d1b antikoerper
    Hintergrund
    Synonyms:EAT2 Background:Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule(SLAM) family such as CD84, SLAMF1, LY9 and CD244(PubMed:11689425). In SLAM signaling seems to cooperate with SH2D1A/SAP. Plays a role in regulation of effector functions of natural killer(NK) cells by controlling signal transduction through CD244/2B4 without effecting its tyrosine phosphorylation, downstream signaling involves PLCG1 and ERK activation(PubMed:24687958). Activation of SLAMF7-mediated NK cell function does not effect receptor tyrosine phosphorylation but distal signaling(By similarity). In the context of NK cell-mediated cytotoxicity does not enhance conjugate formation with target cells but stimulates polarization of the microtubule-organizing center and cytotoxic granules toward the NK cell synapse(PubMed:24687958). Negatively regulates CD40-induced cytokine procuction dendritic cells downstream of SLAM family receptors probably by inducing activation of the PI3K pathway to inhibit p38 MAPK and JNK activation(By similarity).
    Molekulargewicht
    15 kDa
    Gen-ID
    117157
    UniProt
    O14796
    Pathways
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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