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THO Complex 5 Antikörper

THOC5 Reaktivität: Human, Maus, Ratte ELISA, WB, IHC, IP, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7119927
  • Target Alle THO Complex 5 (THOC5) Antikörper anzeigen
    THO Complex 5 (THOC5)
    Reaktivität
    • 26
    • 7
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 25
    • 1
    Kaninchen
    Klonalität
    • 26
    Polyklonal
    Konjugat
    • 16
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser THO Complex 5 Antikörper ist unkonjugiert
    Applikation
    • 13
    • 9
    • 7
    • 4
    • 3
    • 3
    • 1
    • 1
    ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)
    Aufreinigung
    Immunogen affinity purified
    Reinheit
    ≥95 % as determined by SDS-PAGE
    Immunogen
    THO complex 5
    Isotyp
    IgG
    Top Product
    Discover our top product THOC5 Primärantikörper
  • Applikationshinweise
    WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    Haltbarkeit
    12 months
  • Target
    THO Complex 5 (THOC5)
    Andere Bezeichnung
    THOC5 (THOC5 Produkte)
    Synonyme
    C22orf19 antikoerper, Fmip antikoerper, PK1.3 antikoerper, fSAP79 antikoerper, 1700060C24Rik antikoerper, A430085L24Rik antikoerper, Sgk2 antikoerper, fc54b09 antikoerper, wu:fc54b09 antikoerper, zgc:56190 antikoerper, zgc:76912 antikoerper, THOC5 antikoerper, fmip antikoerper, thoc5 antikoerper, thoc5-a antikoerper, thoc5-b antikoerper, THO complex 5 antikoerper, THO complex 5 S homeolog antikoerper, THO complex 5 L homeolog antikoerper, THOC5 antikoerper, Thoc5 antikoerper, thoc5 antikoerper, thoc5.S antikoerper, thoc5.L antikoerper
    Hintergrund
    Synonyms:C22orf19, KIAA0983 Background:Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex(EJC) and is recruited in a splicing-and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus(KSHV) intronless mRNAs and infectious virus production. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA, both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes, probably mediates association of the TREX and CFIm complexes. Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development.
    Molekulargewicht
    79 kDa
    Gen-ID
    8563
    UniProt
    Q13769
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