TNIP1 Antikörper

Produktnummer ABIN7119995

Produktdetails anti-TNIP1 Antikörper

Target: TNIP1 (TNFAIP3 Interacting Protein 1 (TNIP1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TNIP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: TNFAIP3 interacting protein 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200, IF: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu TNIP1

Target: TNIP1 (TNFAIP3 Interacting Protein 1 (TNIP1))

Andere Bezeichnung: TNIP1 (TNIP1 Produkte)

Synonyme: ABIN-1 antikoerper, NAF1 antikoerper, VAN antikoerper, nip40-1 antikoerper, ABIN antikoerper, ABIN1 antikoerper, AU018810 antikoerper, Naf1 antikoerper, Nef antikoerper, im:7141452 antikoerper, naf1 antikoerper, zgc:158159 antikoerper, tnip1 antikoerper, MGC147597 antikoerper, TNFAIP3 interacting protein 1 antikoerper, TNFAIP3 interacting protein 1 S homeolog antikoerper, TNFAIP3-interacting protein 1 antikoerper, TNIP1 antikoerper, Tnip1 antikoerper, tnip1 antikoerper, tnip1.S antikoerper, LOC100078195 antikoerper

Hintergrund: Synonyms:KIAA0113, NAF1 Background:Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG, proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway, blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity, this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation, this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC(Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection.

Molekulargewicht: 72 kDa

Gen-ID: 10318

UniProt: Q15025

Pathways: Activation of Innate immune Response