Tubulin Antikörper (acLys40)

Produktnummer ABIN7120355

Der Maus Monoklonal Anti-Tubulin-Antikörper wurde für WB, IF, ELISA und IHC validiert. Er ist geeignet, Tubulin in Proben von Human, Maus, Hund und Ratte zu detektieren.

Kurzübersicht für Tubulin Antikörper (acLys40) (ABIN7120355)

Target: Tubulin (TUB)

Reaktivität: Human, Maus, Hund, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Tubulin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), ELISA, Immunohistochemistry (IHC)

Klon: 6A10

Produktdetails anti-Tubulin Antikörper

Bindungsspezifität: acLys40

Aufreinigung: Protein A+G purification

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: tubulin, alpha 1a

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:5000, IF: 1:20-1:200, IHC: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu Tubulin

Target: Tubulin (TUB)

Andere Bezeichnung: tubulin

Hintergrund: Synonyms:Acetylated alpha tubulin, Acetylated tubulin, acetylated-a-tubulin, acetyl-a-tubulin, alpha tubulin, Alpha tubulin 3, tubulin,TUBA1A Background:Tubulin, composed of heterodimers of alpha and beta tubulin, is the mainly component of microtubules which play important roles in cell motility, mitosis, and intracellular vesicle transport. Both alpha and beta tubulin undergo several posttranslational modifications such as polyglutamylation and acetylation/deacetylation. Tubulin acetylation occurs on lysine-40 at the N-terminal of alpha tubulin and is conserved across species. The histone deacetylase HDAC6 and SIRT2 has been identified as tubulin deacetylases. Reversible acetylation of alpha tubulin may be implicated in regulating microtubule stability, cell motility, and axon regeneration. The level of acetylated tubulin has been linked to epithelial malignancies and sensitivity to chemotherapy. In addition, acetylated tubulin has been widely used as a marker for primary cilia. This antibody is specific to the acetylated tubulin, it does not recognize non-acetylated tubulin.

Molekulargewicht: 52 kDa

Gen-ID: 7846

UniProt: Q71U36