Rekombinanter CDX2 Antikörper

Produktnummer ABIN7504139

Produktdetails anti-CDX2 Antikörper

Target: CDX2 (Caudal Type Homeobox 2 (CDX2))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Synthetic

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser CDX2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Spezifität: The intestine-specific transcription factors CDX1 and CDX2 are important for directing intestinal development, differentiation, proliferation and maintenance of the intestinal phenotype. CDX2 protein expression has been seen in GI carcinomas. Anti-CDX2 has been useful to establish GI origin of metastatic adenocarcinomas and carcinoidsand is especially useful to distinguish metastatic colorectal adenocarcinoma from lung adenocarcinoma.However, mucinous carcinomas of the ovary also express CDX2 protein. It limits the usefulness of this marker in the distinction of metastatic colorectal adenocarcinoma from mucinous carcinoma of the ovary.

Kreuzreaktivität (Details): Human.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragments and synthetic peptides from human CDX2 protein (exact sequences are proprietary)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Positive Control: HT29 cells. Human colon carcinoma

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA and 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8 °C. Antibody is stable for 24 months. Non-hazardous. Also available WITHOUT BSA & azide at 1.0mg/ml.

Haltbarkeit: 24 months

Details zu CDX2

Target: CDX2 (Caudal Type Homeobox 2 (CDX2))

Andere Bezeichnung: CDX2 (CDX2 Produkte)

Synonyme: CDX2 antikoerper, MGC130987 antikoerper, cdx3-like antikoerper, CDX-3 antikoerper, CDX3 antikoerper, CDX-2 antikoerper, Cdx-2 antikoerper, caudal type homeobox 2 antikoerper, caudal type homeobox 2 L homeolog antikoerper, caudal type homeo box 2 antikoerper, CDX2 antikoerper, cdx2.L antikoerper, Cdx2 antikoerper

Hintergrund: Caudal type homeobox 2, Caudal type homeobox transcription factor 2, Caudal-type homeobox protein 2, CDX2,CDX2 / Caudal Type Homeobox 2 (GI Epithelial Marker)
Cellular localisation: Nuclear

Molekulargewicht: 40kDa

Gen-ID: 1045, 174249

UniProt: Q99626

Pathways: Peptide Hormone Metabolism, Stem Cell Maintenance