SMNDC1 Antikörper
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- Target Alle SMNDC1 Antikörper anzeigen
- SMNDC1 (Survival Motor Neuron Domain Containing 1 (SMNDC1))
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser SMNDC1 Antikörper ist unkonjugiert
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Applikation
- Flow Cytometry (FACS), Immunofluorescence (IF)
- Spezifität
- SPF30 (survival of motor neuron-related-splicing factor 30), also known as SMNDC1 (survival motor neuron domain containing 1) or SMNR (SMN-related protein), is an essential splicing factor required for spliceosome assembly that belongs to the SMN family. It contains one Tudor domain with significant similarity to SMN (survival motor neuron) and is expressed in skeletal muscle, pancreas and heart, localizing to Cajal bodies and nuclear speckles. SPF30 plays an important role in spliceosome assembly and directly interacts with five U snRNPs. The loss of SPF30 causes spliceosome assembly to arrest at prespliceosomes (A complex). This supports a function for SPF30 in mediating the incorporation/recruitment of U4/U5/U6 tri-snRNP to the prespliceosome. In addition, the overexpression of SPF30 can lead to apoptosis.
- Kreuzreaktivität (Details)
- Human.
- Aufreinigung
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Recombinant full-length human SMNDC1 protein
- Isotyp
- IgG2b
- Top Product
- Discover our top product SMNDC1 Primärantikörper
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- Applikationshinweise
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Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.
Positive_Control: HeLa or HepG2 cells.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Konservierungsmittel
- Azide free
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Haltbarkeit
- 24 months
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- Target
- SMNDC1 (Survival Motor Neuron Domain Containing 1 (SMNDC1))
- Andere Bezeichnung
- SMNDC1 (SMNDC1 Produkte)
- Synonyme
- smnr antikoerper, spf30 antikoerper, SMNDC1 antikoerper, SMNR antikoerper, SPF30 antikoerper, TDRD16C antikoerper, wu:fb37h07 antikoerper, wu:fc23a07 antikoerper, 2410004J23Rik antikoerper, 4933440I19Rik antikoerper, survival motor neuron domain containing 1 antikoerper, smndc1 antikoerper, SMNDC1 antikoerper, Bm1_41545 antikoerper, Smndc1 antikoerper
- Hintergrund
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30 kDa splicing factor SMNrp, MGC106917, MGC112663, SMN related protein, SMNR, SPF30, Splicing factor 30, survival of motor neuron-related, Survival motor neuron domain containing protein 1, Survival of motor neuron related splicing factor 30,SMNDC1
Cellular localisation: Nucleus. Detected in nuclear speckles containing snRNP and in Cajal (coiled) bodies. - Molekulargewicht
- 30kDa
- Gen-ID
- 10285, 632093
- UniProt
- O75940
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