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ECD/SGT1 Antikörper

ECD Reaktivität: Human IP, IF, FACS Wirt: Maus Monoclonal unconjugated
Produktnummer ABIN7126219
  • Target Alle ECD/SGT1 (ECD) Antikörper anzeigen
    ECD/SGT1 (ECD) (Ecdysoneless Homolog (ECD))
    Reaktivität
    • 25
    • 5
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    Human
    Wirt
    • 21
    • 4
    Maus
    Klonalität
    • 22
    • 3
    Monoklonal
    Konjugat
    • 15
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ECD/SGT1 Antikörper ist unkonjugiert
    Applikation
    • 15
    • 9
    • 4
    • 3
    • 2
    • 1
    Immunoprecipitation (IP), Immunofluorescence (IF), Flow Cytometry (FACS)
    Spezifität
    Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP. May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes. Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins. The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex. May play a role in regulation of pre-mRNA splicing.
    Kreuzreaktivität (Details)
    Human. Predicted to react with Rabbit, Goat, Horse, Guinea pig, Dog, Pig, Rhesus monkey, Orangutan and Elephant (based on sequence homology).
    Aufreinigung
    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
    Immunogen
    Recombinant full-length human ECD protein
    Isotyp
    IgG2b
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  • Applikationshinweise

    Known_Application: Immunoprecipitation (1-2 μg per 100-500 μg of total protein), ,Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.

    Positive_Control: HeLa or 293T cells. Human testis, spleen or colon.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    Prepared in 10 mM PBS, WITHOUT BSA and Azide.
    Konservierungsmittel
    Azide free
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
    Haltbarkeit
    24 months
  • Target
    ECD/SGT1 (ECD) (Ecdysoneless Homolog (ECD))
    Andere Bezeichnung
    ECD (ECD Produkte)
    Hintergrund
    Ecdysoneless homolog, hSGT1, Human suppressor of GCR two, Protein ecdysoneless homolog, SGT1 protein,ECD / SGT1
    Cellular localisation: Nucleus. Cytosol.
    Molekulargewicht
    72.76kDa
    Gen-ID
    11319, 631822
    UniProt
    O95905
    Pathways
    Regulation of Carbohydrate Metabolic Process
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