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E4F1 Antikörper

E4F1 Reaktivität: Human IF, FACS Wirt: Maus Monoclonal unconjugated
Produktnummer ABIN7126308
  • Target Alle E4F1 Antikörper anzeigen
    E4F1 (E4F Transcription Factor 1 (E4F1))
    Reaktivität
    • 10
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 7
    • 3
    Maus
    Klonalität
    • 9
    • 1
    Monoklonal
    Konjugat
    • 10
    Dieser E4F1 Antikörper ist unkonjugiert
    Applikation
    • 9
    • 3
    • 3
    • 2
    • 1
    • 1
    Immunofluorescence (IF), Flow Cytometry (FACS)
    Spezifität
    E4F1 (E4F transcription factor 1), also known as E4F, is a 784 amino acid protein that localizes to both the nucleus and the cytoplasm and contains 9 C2H2-type zinc fingers. Expressed ubiquitously in adult and fetal tissues, E4F1 exists as a homodimer that binds DNA and is thought to act as a transcriptional repressor and may also play a role in cell survival and growth via cell cycle control. Additionally, E4F1 is thought to function as a ubiquitin ligase that mediates the ubiquitination (and subsequent degradation) of target proteins and may be involved in the p53 tumor suppressor pathway. E4F1, which may be post-translationally phosphorylated or sumoylated, is subject to proteolytic cleavage which results in the creation of a short peptide with specific DNA binding capabilities.
    Kreuzreaktivität (Details)
    Human
    Aufreinigung
    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
    Immunogen
    Recombinant full-length human E4F1 protein
    Isotyp
    IgG1
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    Discover our top product E4F1 Primärantikörper
  • Applikationshinweise

    Known_Application: Flow Cytometry (1-2 μg/million cells), ,Immunofluorescence (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.

    Positive_Control: HeLa, Jurkat or MCF7 cells.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    Prepared in 10 mM PBS, WITHOUT BSA and Azide.
    Konservierungsmittel
    Azide free
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
    Haltbarkeit
    24 months
  • Target
    E4F1 (E4F Transcription Factor 1 (E4F1))
    Andere Bezeichnung
    E4F1 (E4F1 Produkte)
    Synonyme
    e4f antikoerper, MGC147041 antikoerper, E4F antikoerper, Dnase1l2 antikoerper, zgc:114190 antikoerper, E4F transcription factor 1 antikoerper, E4F transcription factor 1 S homeolog antikoerper, E4F1 antikoerper, e4f1 antikoerper, e4f1.S antikoerper, E4f1 antikoerper
    Hintergrund
    E4F transcription factor 1, isoform CRA_b, P120E4F transcription factor, p50E4F, Putative E3 ubiquitin-protein ligase E4F1, RING type E3 ubiquitin transferase E4F1, Transcription factor E4F1,E4F1
    Cellular localisation: Nucleus.
    Molekulargewicht
    83kDa
    Gen-ID
    1877, 513268
    UniProt
    Q66K89
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