E4F1 Antikörper
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- Target Alle E4F1 Antikörper anzeigen
- E4F1 (E4F Transcription Factor 1 (E4F1))
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser E4F1 Antikörper ist unkonjugiert
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Applikation
- Immunofluorescence (IF), Flow Cytometry (FACS)
- Spezifität
- E4F1 (E4F transcription factor 1), also known as E4F, is a 784 amino acid protein that localizes to both the nucleus and the cytoplasm and contains 9 C2H2-type zinc fingers. Expressed ubiquitously in adult and fetal tissues, E4F1 exists as a homodimer that binds DNA and is thought to act as a transcriptional repressor and may also play a role in cell survival and growth via cell cycle control. Additionally, E4F1 is thought to function as a ubiquitin ligase that mediates the ubiquitination (and subsequent degradation) of target proteins and may be involved in the p53 tumor suppressor pathway. E4F1, which may be post-translationally phosphorylated or sumoylated, is subject to proteolytic cleavage which results in the creation of a short peptide with specific DNA binding capabilities.
- Kreuzreaktivität (Details)
- Human
- Aufreinigung
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Recombinant full-length human E4F1 protein
- Isotyp
- IgG1
- Top Product
- Discover our top product E4F1 Primärantikörper
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- Applikationshinweise
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Known_Application: Flow Cytometry (1-2 μg/million cells), ,Immunofluorescence (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.
Positive_Control: HeLa, Jurkat or MCF7 cells.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Konservierungsmittel
- Azide free
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Haltbarkeit
- 24 months
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- Target
- E4F1 (E4F Transcription Factor 1 (E4F1))
- Andere Bezeichnung
- E4F1 (E4F1 Produkte)
- Synonyme
- e4f antikoerper, MGC147041 antikoerper, E4F antikoerper, Dnase1l2 antikoerper, zgc:114190 antikoerper, E4F transcription factor 1 antikoerper, E4F transcription factor 1 S homeolog antikoerper, E4F1 antikoerper, e4f1 antikoerper, e4f1.S antikoerper, E4f1 antikoerper
- Hintergrund
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E4F transcription factor 1, isoform CRA_b, P120E4F transcription factor, p50E4F, Putative E3 ubiquitin-protein ligase E4F1, RING type E3 ubiquitin transferase E4F1, Transcription factor E4F1,E4F1
Cellular localisation: Nucleus. - Molekulargewicht
- 83kDa
- Gen-ID
- 1877, 513268
- UniProt
- Q66K89
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