Reelin Antikörper (AA 1796-2115)

Produktnummer ABIN7126322

Produktdetails anti-Reelin Antikörper

Target: Reelin (RELN)

Bindungsspezifität: AA 1796-2115

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Reelin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), ELISA, Immunofluorescence (IF), Coating (Coat), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Spezifität: Reelin (or Reln) is a large glycoprotein that is secreted by Cajal-Retzius cells in the forebrain and by granule neurons in the cerebellum. Reelin was shown to be mutated in reeler mice, a mutation that is associated with widespread disruption of laminated regions of the brain, leading to impaired motor coordination, tremors and ataxia. Reelin protein expression is complex and changes throughout development. Reelin appears to function upstream of Dab1, in a signaling pathway that controls cell positioning in the developing brain, and is also thought to be a direct effector of the neurotrophin BDNF.

Kreuzreaktivität (Details): Human, Mouse and Rodent.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant fragment (around aa 1796-2115) of human RELN protein

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise:

Known_Application: ELISA (For coating, order antibody without BSA), ,Immunoprecipitation (1-2 μg per 100-500 μg of total protein (1 mL of cell lysate)), ,Immunofluorescence (1-2 μg/mL), Western Blot (1-2 μg/mL), ,Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: Human or mouse brain or CNS.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu Reelin

Target: Reelin (RELN)

Andere Bezeichnung: RELN (RELN Produkte)

Synonyme: LIS2 antikoerper, PRO1598 antikoerper, RL antikoerper, reeler antikoerper, rl antikoerper, Reelen antikoerper, Rl antikoerper, reln antikoerper, RELN antikoerper, MGC172539 antikoerper, reelin antikoerper, reelin L homeolog antikoerper, RELN antikoerper, Reln antikoerper, reln antikoerper, reln.L antikoerper, LOC579060 antikoerper

Hintergrund: LIS2, PRO1598, Reeler, Reelin, RELN, RELN_HUMAN, RL,Reelin
Cellular localisation: Cytoplasm

Molekulargewicht: 387.5kDa

Gen-ID: 19699, 655654

UniProt: P78509

Pathways: Synaptic Membrane