GRAMD4 Antikörper

Produktnummer ABIN7126410

Produktdetails anti-GRAMD4 Antikörper

Target: GRAMD4 (GRAM Domain Containing 4 (GRAMD4))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser GRAMD4 Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF), Flow Cytometry (FACS)

Spezifität: The gene encoding GRAMD4 (GRAM domain-containing protein 4) maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome. GRAMD4, also designated death-inducing protein (DIP), is a 578 amino acid mitochondrial membrane protein that acts as an essential mediator of the p53-independent E2F-1 death pathway, which is frequently found to be deregulated in several types of cancers. Overexpression of GRAMD4 results in a strong apoptotic response involving caspase-3 activation and cleavage of poly(ADP-ribose)-polymerase. GRAMD4 is expressed in lung and in primary lung squamous cell carcinoma (LSCC) and shows upregulation in mitochondria by E2F1 after addition of 4-hydroxytamoxifen. This evidence suggests that GRAMD4 may be a potential target for cancer therapies.

Kreuzreaktivität (Details): Human. Predicted to react in Rat.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant full-length human GRAMD4 protein

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.

Positive_Control: Human liver, heart or fetal brain.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu GRAMD4

Target: GRAMD4 (GRAM Domain Containing 4 (GRAMD4))

Andere Bezeichnung: GRAMD4 (GRAMD4 Produkte)

Synonyme: DIP antikoerper, dA59H18.1 antikoerper, dJ439F8.1 antikoerper, 9930016O13 antikoerper, dip antikoerper, GRAM domain containing 4 antikoerper, GRAM domain containing 4 S homeolog antikoerper, GRAMD4 antikoerper, Gramd4 antikoerper, gramd4.S antikoerper

Hintergrund: Death-inducing protein, GRAM domain-containing protein 4 (GRAMD4),GRAMD4 (Transcription Factor)
Cellular localisation: Mitochondrion membrane. Colocalizes with COX4I1.

Molekulargewicht: 66kDa

Gen-ID: 23151, 475150

UniProt: Q6IC98