RHOBTB2 Antikörper (AA 554-604)

Produktnummer ABIN7126412

Produktdetails anti-RHOBTB2 Antikörper

Target: RHOBTB2 (rho-Related BTB Domain Containing 2 (RHOBTB2))

Bindungsspezifität: AA 554-604

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser RHOBTB2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Spezifität: The Rho subfamily of Ras-related GTPases controls multiple aspects of cell function, including cytoskeletal rearrangement, nuclear signaling and cell growth. DBC-2 (deleted in breast cancer 2 gene protein), also known as RHOBTB2 (Rho-related BTB domain-containing protein 2), is a 727 amino acid member of the RhoBTB subfamily of Rho GTPases. Members of the RhoBTB subfamily are evolutionarily conserved and are characterized by a proline-rich region, a GTPase domain and two tandem BTB repeats. Expressed ubiquitously with highest levels in neural tissue, heart, brain and fetal lung, DBC-2 contains two BTB (POZ) domains through which it may bind to and regulate the function of target proteins, such as CUL-3. Additionally, DBC-2 is thought to function as a regulator of cell cycle and apoptosis events. Under normal conditions, DBC-2 is thought to exhibit tumor suppressor activity. Mutations in the gene encoding DBC-2 are associated with breast cancer, suggesting that mutated DBC-2 may play a role in carcinogenesis.

Kreuzreaktivität (Details): Human.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Human recombinant RHOBTB2 protein fragment (around aa 554-604) (exact sequence is proprietary)

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: Human heart muscle or brain tissue.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu RHOBTB2

Target: RHOBTB2 (rho-Related BTB Domain Containing 2 (RHOBTB2))

Andere Bezeichnung: RHOBTB2 (RHOBTB2 Produkte)

Synonyme: DBC2 antikoerper, Dbc2 antikoerper, E130206H14Rik antikoerper, mKIAA0717 antikoerper, Rho related BTB domain containing 2 antikoerper, Rho-related BTB domain containing 2 antikoerper, RHOBTB2 antikoerper, Rhobtb2 antikoerper

Hintergrund: Deleted in breast cancer 2 gene protein, p83, Rho related BTB domain containing protein 2,DBC2 / RHOBTB2
Cellular localisation: Secreted in plasma

Molekulargewicht: 83kDa

Gen-ID: 23221, 372688

UniProt: Q9BYZ6