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RHOBTB2 Antikörper (AA 554-604)

RHOBTB2 Reaktivität: Human IHC (f) Wirt: Maus Monoclonal unconjugated
Produktnummer ABIN7126413
  • Target Alle RHOBTB2 Antikörper anzeigen
    RHOBTB2 (rho-Related BTB Domain Containing 2 (RHOBTB2))
    Bindungsspezifität
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 554-604
    Reaktivität
    • 24
    • 12
    • 1
    Human
    Wirt
    • 20
    • 4
    Maus
    Klonalität
    • 22
    • 2
    Monoklonal
    Konjugat
    • 10
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser RHOBTB2 Antikörper ist unkonjugiert
    Applikation
    • 7
    • 7
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    Spezifität
    The Rho subfamily of Ras-related GTPases controls multiple aspects of cell function, including cytoskeletal rearrangement, nuclear signaling and cell growth. DBC-2 (deleted in breast cancer 2 gene protein), also known as RHOBTB2 (Rho-related BTB domain-containing protein 2), is a 727 amino acid member of the RhoBTB subfamily of Rho GTPases. Members of the RhoBTB subfamily are evolutionarily conserved and are characterized by a proline-rich region, a GTPase domain and two tandem BTB repeats. Expressed ubiquitously with highest levels in neural tissue, heart, brain and fetal lung, DBC-2 contains two BTB (POZ) domains through which it may bind to and regulate the function of target proteins, such as CUL-3. Additionally, DBC-2 is thought to function as a regulator of cell cycle and apoptosis events. Under normal conditions, DBC-2 is thought to exhibit tumor suppressor activity. Mutations in the gene encoding DBC-2 are associated with breast cancer, suggesting that mutated DBC-2 may play a role in carcinogenesis.
    Kreuzreaktivität (Details)
    Human.
    Aufreinigung
    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
    Immunogen
    Human recombinant RHOBTB2 protein fragment (around aa554-604) (exact sequence is proprietary)
    Isotyp
    IgG2
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  • Applikationshinweise

    Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

    Positive_Control: Human heart muscle or brain tissue.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    Prepared in 10 mM PBS, WITHOUT BSA and Azide.
    Konservierungsmittel
    Azide free
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
    Haltbarkeit
    24 months
  • Target
    RHOBTB2 (rho-Related BTB Domain Containing 2 (RHOBTB2))
    Andere Bezeichnung
    RHOBTB2 (RHOBTB2 Produkte)
    Synonyme
    DBC2 antikoerper, Dbc2 antikoerper, E130206H14Rik antikoerper, mKIAA0717 antikoerper, Rho related BTB domain containing 2 antikoerper, Rho-related BTB domain containing 2 antikoerper, RHOBTB2 antikoerper, Rhobtb2 antikoerper
    Hintergrund
    Deleted in breast cancer 2 gene protein, p83, Rho related BTB domain containing protein 2,DBC2 / RHOBTB2
    Cellular localisation: Secreted in plasma
    Molekulargewicht
    83kDa
    Gen-ID
    23221, 372688
    UniProt
    Q9BYZ6
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