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Rekombinanter INSM1 Antikörper (AA 81-125)

INSM1 Reaktivität: Human IHC (f) Wirt: Kaninchen Monoclonal unconjugated Recombinant Antibody
Produktnummer ABIN7126595
  • Target Alle INSM1 Antikörper anzeigen
    INSM1 (Insulinoma-Associated 1 (INSM1))
    Antikörpertyp
    Recombinant Antibody
    Bindungsspezifität
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 81-125
    Reaktivität
    • 17
    • 14
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 17
    • 1
    Kaninchen
    Klonalität
    • 16
    • 2
    Monoklonal
    Konjugat
    • 11
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser INSM1 Antikörper ist unkonjugiert
    Applikation
    • 9
    • 6
    • 3
    • 2
    • 2
    • 1
    Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    Spezifität
    Insulinoma-associated protein 1 (INSM1) is a developmentally regulated zinc-finger transcription factor. It localizes to the nucleus and is expressed in embryonic issues undergoing neuroendocrine differentiation. INSM1 is not expressed in normal adult tissues but can be found highly expressed in neuroendocrine tumors. INSM1 is positive in 95 % of lung small cell carcinoma and 91 % of lung large cell neuroendocrine carcinoma, compared with 75 % and 78 % with the combined panel of traditional neuroendocrine markers (synaptophysin, chromogranin, and CD56).INSM1 stains 100 % of the atypical carcinoids, typical carcinoids and paragangliomas, but only 3 % of adenocarcinomas and 4 % of squamous cell carcinomas. Therefore, INSM1 is sensitive and specific to be a single first-line pan-neuroendocrine marker.
    Kreuzreaktivität (Details)
    Human.
    Aufreinigung
    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
    Immunogen
    Recombinant fragment (around aa81-125) corresponding to the N-terminus of human INSM1
    Isotyp
    IgG
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  • Applikationshinweise

    Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

    Positive_Control: Human pancreas or neuroendocrine tumor.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    Prepared in 10 mM PBS, WITHOUT BSA and Azide.
    Konservierungsmittel
    Azide free
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
    Haltbarkeit
    24 months
  • Target
    INSM1 (Insulinoma-Associated 1 (INSM1))
    Andere Bezeichnung
    INSM1 (INSM1 Produkte)
    Synonyme
    IA-1 antikoerper, IA1 antikoerper, INSM-1 antikoerper, Insm1 antikoerper, fc13a09 antikoerper, wu:fc13a09 antikoerper, zINSM-1 antikoerper, zgc:63866 antikoerper, INSM1 antikoerper, ia-1 antikoerper, zgc:77257 antikoerper, INSM transcriptional repressor 1 antikoerper, insulinoma-associated 1 antikoerper, insulinoma-associated 1b antikoerper, insulinoma associated 1 antikoerper, insulinoma associated 1 L homeolog antikoerper, insulinoma-associated 1a antikoerper, INSM1 antikoerper, Insm1 antikoerper, insm1b antikoerper, insm1 antikoerper, insm1.L antikoerper, insm1a antikoerper
    Hintergrund
    IA1, Insulinoma associated protein 1 (IA1), Zinc finger protein IA1,INSM1 (Pan-Neuroendocrine Marker)
    Cellular localisation: Nuclear
    Molekulargewicht
    58kDa
    Gen-ID
    3642, 89584
    UniProt
    Q01101
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