Rekombinanter NKX3-1 Antikörper (AA 92-224)

Produktnummer ABIN7126747

Produktdetails anti-NKX3-1 Antikörper

Target: NKX3-1 (NK3 Homeobox 1 (NKX3-1))

Antikörpertyp: Recombinant Antibody

Bindungsspezifität: AA 92-224

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser NKX3-1 Antikörper ist unkonjugiert

Applikation: ELISA, Coating (Coat), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Spezifität: NKX3.1 is a prostate specific gene encoding a transcription factor that plays an important role in normal prostate development and carcinogenesis. It is a prostatic tumor suppressor gene located on chromosome 8p21.2, which frequently undergoes a loss of heterozygosity. NKX3.1 expression is highly restricted in prostate epithelial cells and therefore can be used as a diagnostic biomarker for prostate cancer and other metastatic lesions of prostatic origin. Furthermore, NKX3.1 shows better sensitivity than Prostate Specific Antigen (PSA) for identifying metastatic prostatic adenocarcinoma. This suggests that immunohistochemical staining of NKX3.1, along with other prostate-restricted markers, may be valuable for the definitive determination of prostatic origin in poorly differentiated metastatic carcinomas.

Kreuzreaktivität (Details): Human.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant fragment (around aa 92-224) of human NKX3.1 protein (exact sequence is proprietary)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Known_Application: ELISA (For coating, order Ab without BSA),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: Highly expressed in the prostate and at a lower level in the testis.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu NKX3-1

Target: NKX3-1 (NK3 Homeobox 1 (NKX3-1))

Andere Bezeichnung: NKX3-1 (NKX3-1 Produkte)

Synonyme: Xbagpipe antikoerper, Xbap antikoerper, bagpipe antikoerper, koza antikoerper, nkx3-1 antikoerper, nkx3.1 antikoerper, si:ch211-67o1.2 antikoerper, nkx3a antikoerper, MGC53041 antikoerper, MGC97890 antikoerper, Bax antikoerper, NKX3.1 antikoerper, NKX3A antikoerper, Nkx-3.1 antikoerper, BAPX2 antikoerper, NKX3 antikoerper, NK3 homeobox 1 L homeolog antikoerper, NK3 homeobox 1 antikoerper, NK-3 transcription factor, locus 1 (Drosophila) antikoerper, nkx3-1.L antikoerper, NKX3-1 antikoerper, nkx3-1 antikoerper, Nkx3-1 antikoerper

Hintergrund: NK3 Homeobox 1, Homeobox Protein NK-3 Homolog A, NKX3-1, NKX3A, NK3 Transcription Factor Related, Locus 1 (Drosophila), NK3 Transcription Factor Related, Locus 1, NK Homeobox (Drosophila), Family 3, A, NK3 Transcription Factor Homolog A, NK Homeobox, Family 3, A, Homeobox Protein Nkx-3.1, BAPX2, NKX3,NKX3.1 (Metastatic Prostate Adenocarcinoma Marker)
Cellular localisation: Nuclear

Molekulargewicht: 35kDa

Gen-ID: 4824, 55999

UniProt: Q99801

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Endopeptidase Activity, Positive Regulation of Response to DNA Damage Stimulus