Rekombinanter S100P Antikörper (C-Term)

Produktnummer ABIN7126919

Produktdetails anti-S100P Antikörper

Target: S100P (S100 Calcium Binding Protein P (S100P))

Antikörpertyp: Recombinant Antibody

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser S100P Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Spezifität: S100P is a 95-amino-acid protein and a member of the S100 family. S100P has been shown to mediate tumor growth, metastasis and invasion through the binding of Ca2+ ions, receptor for advanced glycation end products, cytoskeletal protein ezrin, calcyclin-binding protein/Siah-1-interacting protein and cathepsin D.S100P highly expressed in human placenta, gastrointestinal tract, and esophageal mucosa, but always negative in pancreas and liver. Overexpression of S100P has been detected in several cancers such as breast, colon, prostate, pancreatic and lung carcinomas, and the protein has been functionally implicated in carcinogenic processes. S100P could potentially serve as diagnostic marker, prognostic/predictive indicator and therapy target for different carcinomas.

Kreuzreaktivität (Details): Human.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant fragment corresponding to C-terminal of human S100P protein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: Human pancreatic adenocarcinoma, placenta or spleen tissue.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu S100P

Target: S100P (S100 Calcium Binding Protein P (S100P))

Andere Bezeichnung: S100P (S100P Produkte)

Synonyme: MIG9 antikoerper, S100P antikoerper, S100p antikoerper, S100 calcium binding protein P antikoerper, S100 calcium binding protein B antikoerper, S100 calcium binding protein P pseudogene antikoerper, S100P antikoerper, s100p antikoerper, S100b antikoerper, S100p antikoerper, Gm40318 antikoerper

Hintergrund: Migration inducing gene 9 (MIG9), S100E, S100 calcium binding protein P,S100P
Cellular localisation: Nucleus. Cytoplasm. Colocalizes with S100PBP in the nucleus.

Molekulargewicht: 10kDa

Gen-ID: 6286, 2962

UniProt: P25815

Pathways: Regulation of Muscle Cell Differentiation, Toll-Like Receptors Cascades, S100 Proteine