PARVG Antikörper

Produktnummer ABIN7126930

Produktdetails anti-PARVG Antikörper

Target: PARVG (Parvin, gamma (PARVG))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PARVG Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Spezifität: The parvin family, including α-parvin, β-parvin and γ-parvin, link integrins and associated proteins with intracellular pathways, which regulate actin cytoskeletal dynamics and cell survival. All three family members localize to focal adhesions and function in cell adhesion, spreading, motility and survival through interactions with partners, such as integrin-linked kinase (ILK), paxillin, α-actinin and testicular kinase 1. α-parvin is widely expressed, with highest levels detected in the skeletal muscle, heart, liver and kidney. A complex made up of α-parvin, ILK and the LIM protein PINCH-1 is critical for cell survival in a variety of cells, including certain cancer cells, kidney podocytes and cardiac myocytes. β-parvin links initial integrin signals to rapid actin reorganization, thereby playing a critical role in fibroblast migration. The ILK-γ-parvin complex is essential for the establishment of cell polarity required for leukocyte migration.

Kreuzreaktivität (Details): Human.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: GST-tagged recombinant protein corresponding to human Gamma-parvin

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

Known_Application: Immunoprecipitation (1-2 μg per 100-500 μg of total protein (1 mL of cell lysate)), ,Western Blot (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.

Positive_Control: Jurkat cell lysate.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu PARVG

Target: PARVG (Parvin, gamma (PARVG))

Andere Bezeichnung: PARVG (PARVG Produkte)

Synonyme: PARVG antikoerper, AI413459 antikoerper, parvin gamma antikoerper, parvin gamma S homeolog antikoerper, parvin, gamma antikoerper, PARVG antikoerper, parvg.S antikoerper, Parvg antikoerper

Hintergrund: Gamma parvin, PARVG,Gamma-parvin
Cellular localisation: Cytoplasm. Cell Surface.

Molekulargewicht: 37kDa

Gen-ID: 64098

UniProt: Q9HBI0