Rekombinanter p63 Antikörper (AA 1-100)
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- Target Alle p63 (TP63) Antikörper anzeigen
- p63 (TP63) (Tumor Protein P63 (TP63))
- Antikörpertyp
- Recombinant Antibody
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Bindungsspezifität
- AA 1-100
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Monoklonal
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Konjugat
- Dieser p63 Antikörper ist unkonjugiert
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Applikation
- ELISA, Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Flow Cytometry (FACS), Coating (Coat)
- Spezifität
- P40 antibody (antibody recognizing Np63 only) is an isoform of p63, is thought to function as a stem cell factor, responsible for maintaining cells in an uncommitted state with regenerative potential a role that may be recapitulated in tumors derived from these cells. p40 is normally expressed in the basal or progenitor cell layer of stratified epithelia (eg. squamous, urothelial, bronchial), basal cells of some glandular epithelia (eg. prostate), as well as myoepithelial cells of breast and salivary glands, trophoblasts and thymic epithelial cells. In tumor tissues, p40 expression is specific for squamous cell carcinoma. p40 is equivalent to p63 in sensitivity for lung squamous cell carcinoma, but it is markedly superior to p63 in specificity, which eliminates a potential pitfall of misinterpreting a p63-positive adenocarcinoma or unsuspected lymphoma as squamous cell carcinoma. p40 appears to be a more reliable marker for squamous cell carcinoma.
- Kreuzreaktivität (Details)
- Human.
- Aufreinigung
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Recombinant fragment (around aa1-100) of human p40 protein (exact sequence is proprietary)
- Isotyp
- IgG
- Top Product
- Discover our top product TP63 Primärantikörper
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- Applikationshinweise
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Known_Application: ELISA (For coating, order antibody without BSA), Flow Cytometry (1-2 μg/million cells), ,Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
Positive_Control: HEK293, MDA-MB453 or MCF7 cells. Human prostate, lung or bladder squamous cell carcinoma tissue.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Konservierungsmittel
- Azide free
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Haltbarkeit
- 24 months
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- Target
- p63 (TP63) (Tumor Protein P63 (TP63))
- Andere Bezeichnung
- TP63 (TP63 Produkte)
- Synonyme
- AIS antikoerper, B(p51A) antikoerper, B(p51B) antikoerper, EEC3 antikoerper, KET antikoerper, LMS antikoerper, NBP antikoerper, OFC8 antikoerper, RHS antikoerper, SHFM4 antikoerper, TP53CP antikoerper, TP53L antikoerper, TP73L antikoerper, p40 antikoerper, p51 antikoerper, p53CP antikoerper, p63 antikoerper, p73H antikoerper, p73L antikoerper, TP63 antikoerper, tp63 antikoerper, DNp63 antikoerper, id:ibd3516 antikoerper, tp73l antikoerper, wu:fc89f04 antikoerper, wu:fk85h07 antikoerper, wu:fk88b02 antikoerper, Ket antikoerper, P73l antikoerper, Tp73l antikoerper, Trp63 antikoerper, TRP63 antikoerper, AI462811 antikoerper, P51/P63 antikoerper, P63 antikoerper, Tp63 antikoerper, Trp53rp1 antikoerper, Xp63 antikoerper, ket antikoerper, np63 antikoerper, tp73l-A antikoerper, trp63 antikoerper, tumor protein p63 antikoerper, transformation related protein 63 antikoerper, tumor protein p63 L homeolog antikoerper, TP63 antikoerper, tp63 antikoerper, Tp63 antikoerper, Trp63 antikoerper, tp63.L antikoerper
- Hintergrund
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Amplified in squamous cell carcinoma (AIS), Chronic ulcerative stomatitis protein (CUSP), EEC3, TP73L, LMS, TP63, Keratinocyte transcription factor KET, NBP, P51/P63, p53 like transcription factor, RHS, SHFM4, TAp63alpha, TP53CP, TP53L, Transformation-related protein 63, Trp53rp1, Trp6,3, Tumor protein p53-like, tumor protein p73-like,p40 (Squamous, Basal & Myoepithelial Cell Marker)
Cellular localisation: Nucleus. - Molekulargewicht
- 63kDa
- Gen-ID
- 8626, 137569
- UniProt
- Q9H3D4
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