Rekombinanter H2AFX Antikörper (pSer139)
-
- Target Alle H2AFX Antikörper anzeigen
- H2AFX (H2A Histone Family, Member X (H2AFX))
- Antikörpertyp
- Recombinant Antibody
-
Bindungsspezifität
- pSer139
-
Reaktivität
- Human
-
Wirt
- Kaninchen
-
Klonalität
- Monoklonal
-
Konjugat
- Dieser H2AFX Antikörper ist unkonjugiert
-
Applikation
- Western Blotting (WB), ELISA
- Kreuzreaktivität
- Human
- Aufreinigung
- Affinity-chromatography
- Immunogen
- A synthesized peptide
- Klon
- 1F10
- Isotyp
- IgG
- Top Product
- Discover our top product H2AFX Primärantikörper
-
-
- Applikationshinweise
- Recommended dilution: WB:1:3000-1:10000,
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Liquid
- Buffer
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
- Target
- H2AFX (H2A Histone Family, Member X (H2AFX))
- Andere Bezeichnung
- H2AFX (H2AFX Produkte)
- Hintergrund
-
Background: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
Aliases: Histone H2AX, H2a/x, Histone H2A.X, H2AFX, H2AX
- UniProt
- P16104
- Pathways
- Telomere Maintenance, DNA Reparatur, Positive Regulation of Response to DNA Damage Stimulus
-