Rekombinanter EIF2C3 Antikörper

Produktnummer ABIN7127326

Produktdetails anti-EIF2C3 Antikörper

Target: EIF2C3 (Eukaryotic Translation Initiation Factor 2C3 (EIF2C3))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser EIF2C3 Antikörper ist unkonjugiert

Applikation: ELISA

Kreuzreaktivität: Human

Aufreinigung: Affinity-chromatography

Immunogen: A synthesized peptide derived from human AGO3

Klon: 4F7

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu EIF2C3

Target: EIF2C3 (Eukaryotic Translation Initiation Factor 2C3 (EIF2C3))

Andere Bezeichnung: AGO3 (EIF2C3 Produkte)

Synonyme: EIF2C3 antikoerper, Eif2c3 antikoerper, Argonaute3 antikoerper, ago3 antikoerper, eif2c3 antikoerper, eif2c3b antikoerper, si:dkey-3n22.3 antikoerper, AW048688 antikoerper, C130014L07Rik antikoerper, ARGONAUTE 3 antikoerper, T19E23.8 antikoerper, T19E23_8 antikoerper, argonaute 3, RISC catalytic component antikoerper, argonaute RISC catalytic component 3b antikoerper, argonaute RISC catalytic subunit 3 antikoerper, argonaute RISC catalytic component 3 antikoerper, ARGONAUTE 3 antikoerper, AGO3 antikoerper, Ago3 antikoerper, ago3b antikoerper

Hintergrund:

Background: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Proposed to be involved in stabilization of small RNA derivates (riRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent riRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4. Possesses RNA slicer activity but only on select RNAs bearing 5'- and 3'-flanking sequences to the region of guide-target complementarity (PubMed:29040713).

Aliases: Protein argonaute-3UniRule annotation, Argonaute RISC catalytic component 3, Eukaryotic translation initiation factor 2C 3UniRule annotation, AGO3, EIF2C3

UniProt: Q9H9G7

Pathways: Fc-epsilon Rezeptor Signalübertragung, Regulatorische RNA Pathways, EGFR Signaling Pathway, Neurotrophin Signalübertragung