Rekombinanter ALIX Antikörper

Produktnummer ABIN7127335

Produktdetails anti-ALIX Antikörper

Target: ALIX (PDCD6IP) (Programmed Cell Death 6 Interacting Protein (PDCD6IP))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser ALIX Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Kreuzreaktivität: Human, Ratte

Aufreinigung: Affinity-chromatography

Immunogen: A synthesized peptide derived from human ALIX

Klon: 7E9

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:5000, FC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu ALIX

Target: ALIX (PDCD6IP) (Programmed Cell Death 6 Interacting Protein (PDCD6IP))

Andere Bezeichnung: PDCD6IP (PDCD6IP Produkte)

Synonyme: DDBDRAFT_0167145 antikoerper, DDBDRAFT_0185177 antikoerper, DDB_0167145 antikoerper, DDB_0185177 antikoerper, AIP1 antikoerper, ALIX antikoerper, DRIP4 antikoerper, HP95 antikoerper, AI480591 antikoerper, AW544830 antikoerper, Aip1 antikoerper, Alix antikoerper, C76364 antikoerper, Eig2 antikoerper, mKIAA1375 antikoerper, CG12876 antikoerper, DAIP1 antikoerper, Dmel\\CG12876 antikoerper, GB11744 antikoerper, RGD1561176 antikoerper, zgc:63638 antikoerper, wu:fb70d03 antikoerper, wu:fy65h02 antikoerper, PDCD6IP antikoerper, aip1 antikoerper, alix antikoerper, hp95 antikoerper, drip4 antikoerper, ALG-2 interacting protein X antikoerper, programmed cell death 6 interacting protein antikoerper, programmed cell death 6-interacting protein antikoerper, Programmed cell death 6 interacting protein antikoerper, programmed cell death 6 interacting protein L homeolog antikoerper, alxA antikoerper, PDCD6IP antikoerper, Pdcd6ip antikoerper, ALiX antikoerper, LOC412662 antikoerper, pdcd6ip antikoerper, Bm1_48390 antikoerper, pdcd6ip.L antikoerper

Hintergrund:

Background: Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes (PubMed:14739459). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:17853893, PubMed:17556548). Adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis (PubMed:17853893, PubMed:17556548, PubMed:18641129). May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP (PubMed:22660413). By interacting with F-actin, PARD3 and TJP1 secures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier (By similarity).

Aliases: Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (Hp95), PDCD6IP, AIP1 ALIX KIAA1375

UniProt: Q8WUM4

Pathways: p53 Signalweg, EGFR Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Tube Formation