Rekombinanter BUB1B Antikörper

Produktnummer ABIN7127374

Produktdetails anti-BUB1B Antikörper

Target: BUB1B (Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast) (BUB1B))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser BUB1B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Kreuzreaktivität: Human

Aufreinigung: Affinity-chromatography

Immunogen: A synthesized peptide derived from human BubR1

Klon: 7H4

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:5000, FC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu BUB1B

Target: BUB1B (Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast) (BUB1B))

Andere Bezeichnung: BUB1B (BUB1B Produkte)

Synonyme: BUB1beta antikoerper, BUBR1 antikoerper, Bub1A antikoerper, MAD3L antikoerper, MVA1 antikoerper, SSK1 antikoerper, hBUBR1 antikoerper, AU045529 antikoerper, bub1b antikoerper, BUB1 antikoerper, BUB1-like antikoerper, BubR1 antikoerper, BubRI antikoerper, CG14030 antikoerper, CG14030/Bub1 antikoerper, Dmel\\CG14030 antikoerper, bub1 antikoerper, BUB1 mitotic checkpoint serine/threonine kinase B antikoerper, BUB1B, mitotic checkpoint serine/threonine kinase antikoerper, BUB1B, mitotic checkpoint serine/threonine kinase L homeolog antikoerper, Mitotic checkpoint serine/threonine-protein kinase BUB1 beta antikoerper, Bub1 kinase antikoerper, BUB1B antikoerper, Bub1b antikoerper, bub1b.L antikoerper, bub1b antikoerper, Bub1 antikoerper

Hintergrund:

Background: Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression.

Aliases: Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1), BUB1B, BUBR1 MAD3L SSK1

UniProt: O60566