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Rekombinanter Cullin 3 Antikörper

CUL3 Reaktivität: Human IHC, ELISA Wirt: Kaninchen Monoclonal 7B6 unconjugated Recombinant Antibody
Produktnummer ABIN7127438
  • Target Alle Cullin 3 (CUL3) Antikörper anzeigen
    Cullin 3 (CUL3)
    Antikörpertyp
    Recombinant Antibody
    Reaktivität
    • 51
    • 24
    • 19
    • 6
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    Human
    Wirt
    • 48
    • 2
    • 1
    Kaninchen
    Klonalität
    • 48
    • 3
    Monoklonal
    Konjugat
    • 30
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Cullin 3 Antikörper ist unkonjugiert
    Applikation
    • 24
    • 15
    • 13
    • 13
    • 12
    • 7
    • 7
    • 4
    • 3
    • 1
    • 1
    Immunohistochemistry (IHC), ELISA
    Kreuzreaktivität
    Human
    Aufreinigung
    Affinity-chromatography
    Immunogen
    A synthesized peptide derived from human Cullin 3
    Klon
    7B6
    Isotyp
    IgG
    Top Product
    Discover our top product CUL3 Primärantikörper
  • Applikationshinweise
    Recommended dilution: IHC:1:50-1:200,
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    Cullin 3 (CUL3)
    Andere Bezeichnung
    CUL3 (CUL3 Produkte)
    Synonyme
    CUL-3 antikoerper, Cullin-3 antikoerper, CUL-3-A antikoerper, Cullin-3-A antikoerper, cul3 antikoerper, cul3a antikoerper, CUL-3-B antikoerper, Cullin-3-B antikoerper, cul3b antikoerper, wu:fc37e01 antikoerper, CUL3 antikoerper, ATCUL3 antikoerper, ATCUL3A antikoerper, CUL3A antikoerper, T24P13.25 antikoerper, cullin 3 antikoerper, cullin 3A antikoerper, PHA2E antikoerper, AI467304 antikoerper, AW146203 antikoerper, mKIAA0617 antikoerper, cullin 3 antikoerper, cullin 3 L homeolog antikoerper, cullin 3 S homeolog antikoerper, cullin-3 antikoerper, Cullin-3 (CUL-3) antikoerper, cullin 3a antikoerper, CULlin antikoerper, CUL3 antikoerper, cul3 antikoerper, cul3.L antikoerper, cul3.S antikoerper, PTRG_11586 antikoerper, Smp_117580 antikoerper, cul3a antikoerper, Cul3 antikoerper, cul-3 antikoerper
    Hintergrund

    Background: Core component of multiple cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the BCR complex depends on the BTB domain-containing protein as the substrate recognition component. BCR(KLHL42) is involved in ubiquitination of KATNA1. BCR(SPOP) is involved in ubiquitination of BMI1/PCGF4, BRMS1, H2AFY and DAXX, GLI2 and GLI3. Can also form a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL, these complexes have lower ubiquitin ligase activity. BCR(KLHL9-KLHL13) controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. BCR(KLHL12) is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B) (PubMed:22358839, PubMed:27716508). BCR(KLHL3) acts as a regulator of ion transport in the distal nephron, by mediating ubiquitination of WNK4 (PubMed:23387299, PubMed:23453970, PubMed:23576762). The BCR(KLHL20) E3 ubiquitin ligase complex is involved in interferon response and anterograde Golgi to endosome transport: it mediates both ubiquitination leading to degradation and 'Lys-33'-linked ubiquitination (PubMed:20389280, PubMed:21840486, PubMed:21670212, PubMed:24768539). The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB (PubMed:19995937). The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation (PubMed:23455478). The BCR(KLHL25) ubiquitin ligase complex is involved in translational homeostasis by mediating ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) (PubMed:22578813). The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in ubiquitination of cyclin E and of cyclin D1 (in vitro) thus involved in regulation of G1/S transition. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41. In concert with ATF2 and RBX1, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. The BCR(KCTD17) E3 ubiquitin ligase complex mediates ubiquitination and degradation of TCHP, a down-regulator of cilium assembly, thereby inducing ciliogenesis (PubMed:25270598). The BCR(KLHL24) E3 ubiquitin ligase complex mediates ubiquitination of KRT14, controls KRT14 levels during keratinocytes differentiation, and is essential for skin integrity (PubMed:27798626).

    Aliases: Cullin-3 (CUL-3), CUL3, KIAA0617

    UniProt
    Q13618
    Pathways
    M Phase
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