Rekombinanter E2F1 Antikörper
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- Target Alle E2F1 Antikörper anzeigen
- E2F1 (E2F Transcription Factor 1 (E2F1))
- Antikörpertyp
- Recombinant Antibody
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Monoklonal
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Konjugat
- Dieser E2F1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)
- Kreuzreaktivität
- Human, Ratte
- Aufreinigung
- Affinity-chromatography
- Immunogen
- A synthesized peptide derived from human E2F1
- Klon
- 1D12
- Isotyp
- IgG
- Top Product
- Discover our top product E2F1 Primärantikörper
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- Applikationshinweise
- Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200, IF:1:20-1:200, FC:1:20-1:200,
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- E2F1 (E2F Transcription Factor 1 (E2F1))
- Andere Bezeichnung
- E2F1 (E2F1 Produkte)
- Hintergrund
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Background: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812).
Aliases: Transcription factor E2F1 (E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1) (Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1), E2F1, RBBP3
- UniProt
- Q01094
- Pathways
- p53 Signalweg, Zellzyklus, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Autophagie
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