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Rekombinanter CD51 Antikörper

ITGAV Reaktivität: Human IHC, ELISA Wirt: Kaninchen Monoclonal 4G7 unconjugated Recombinant Antibody
Produktnummer ABIN7127577
  • Target Alle CD51 (ITGAV) Antikörper anzeigen
    CD51 (ITGAV) (Integrin alpha V (ITGAV))
    Antikörpertyp
    Recombinant Antibody
    Reaktivität
    • 98
    • 56
    • 24
    • 7
    • 6
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 64
    • 35
    • 12
    Kaninchen
    Klonalität
    • 58
    • 52
    Monoklonal
    Konjugat
    • 57
    • 10
    • 8
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CD51 Antikörper ist unkonjugiert
    Applikation
    • 51
    • 50
    • 29
    • 25
    • 22
    • 14
    • 14
    • 13
    • 13
    • 9
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    Immunohistochemistry (IHC), ELISA
    Kreuzreaktivität
    Human
    Aufreinigung
    Affinity-chromatography
    Immunogen
    A synthesized peptide derived from human Integrin alpha V
    Klon
    4G7
    Isotyp
    IgG
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  • Applikationshinweise
    Recommended dilution: IHC:1:50-1:200,
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    CD51 (ITGAV) (Integrin alpha V (ITGAV))
    Andere Bezeichnung
    ITGAV (ITGAV Produkte)
    Synonyme
    1110004F14Rik antikoerper, 2610028E01Rik antikoerper, CD51 antikoerper, D430040G12Rik antikoerper, MSK8 antikoerper, VNRA antikoerper, VTNR antikoerper, Cd51 antikoerper, integrin subunit alpha V antikoerper, integrin alpha V antikoerper, ITGAV antikoerper, Itgav antikoerper
    Hintergrund

    Background: The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 and ITGAV:ITGB6 act as a receptor for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881).

    Aliases: Integrin alpha-V (Vitronectin receptor) (Vitronectin receptor subunit alpha) (CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain, Integrin alpha-V light chain], ITGAV, MSK8 VNRA VTNR

    UniProt
    P06756
    Pathways
    Cell-Cell Junction Organization, Signaling Events mediated by VEGFR1 and VEGFR2, Growth Factor Binding, Integrin Complex
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