Rekombinanter LGR5 Antikörper

Produktnummer ABIN7127600

Produktdetails anti-LGR5 Antikörper

Target: LGR5 (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser LGR5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), ELISA

Kreuzreaktivität: Human, Ratte

Aufreinigung: Affinity-chromatography

Immunogen: A synthesized peptide derived from human LGR5/GPR49

Klon: 4H8

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:5000, FC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu LGR5

Target: LGR5 (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5))

Andere Bezeichnung: LGR5 (LGR5 Produkte)

Synonyme: lgr5-a antikoerper, lgr5a antikoerper, FEX antikoerper, Gpr49 antikoerper, GPR49 antikoerper, GPR67 antikoerper, GRP49 antikoerper, HG38 antikoerper, leucine-rich repeat containing G protein-coupled receptor 5 L homeolog antikoerper, leucine rich repeat containing G protein coupled receptor 5 antikoerper, leucine rich repeat containing G protein-coupled receptor 5 antikoerper, lgr5.L antikoerper, Lgr5 antikoerper, LGR5 antikoerper

Hintergrund:

Background: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.

Aliases: Leucine-rich repeat-containing G-protein coupled receptor 5 (G-protein coupled receptor 49) (G-protein coupled receptor 67) (G-protein coupled receptor HG38), LGR5, GPR49 GPR67

UniProt: O75473

Pathways: WNT Signalweg